Donors 2017-10-07T09:39:12+00:00


As a donor, you are looking to make a difference and leave a legacy in an era of unprecedented clinical innovation. The Center for Genomic Interpretation is powering the next leap forward in clinical genetics to save and improve the lives of millions of genetic patients globally in the fight against hereditary disease and illness. With your help, we can rapidly increase the accuracy of clinical variant interpretation. Together we can ensure that a patient never has to worry about the accuracy of their clinical genetic test.


Genetic testing for a growing number of diseases in adults, children, and fetuses is rapidly becoming common medical practice. Genetic testing has saved the lives of hundreds of thousands of patients, ushering in the era of Precision Medicine. Genetic testing is so powerful in patient care that, for example, the American College of Obstetricians and Gynecologists now recommends that all pregnant women, regardless of age, be offered genetic testing to determine the likelihood of a fetus is at risk for certain genetic diseases.

Like many other medical fields, gene sequencing for disease diagnosis has a greater than 50% false positive rate (on average) due to inaccurate interpretations.  Inaccurate interpretations of genetics is a method and big data problem that CGI knows how to fix. As a 501(c)(3) (pending) non-profit charity, CGI needs financial support from donors to build and apply solutions globally to ensure that genetics patients receive the best diagnoses possible through accurate genetic variant interpretation. Once established, CGI will become self-sustaining. Please help us save and improve lives through donating generously to CGI’s mission.



How common are hereditary diseases? 2017-09-07T16:48:23+00:00

About 8% of Americans are affected by a rare genetic disease. The percentage is roughly the same in European countries. There are many different kinds of genetic diseases with varying levels of severity. Some ancestral populations have a higher prevalence of certain genetic disease(s) than others. Our Hereditary Diseases page lists many of the genetic diseases.

How accurate is genetic testing? 2017-09-07T16:47:19+00:00

There are two major aspects to a genetic test’s accuracy within a laboratory or company; the ability to detect a genetic variant (with accuracy often exceeding 98% for DNA sequencing), and the ability to accurately interpret the genetic variant once detected. The latter step of interpretation is the focus of the Center for Genomic Interpretation since in most genetic testing cases interpretation it is the step that is subject to the greatest error. A laboratory or company’s ability to accurately interpret genetic variants differs widely across the genetic testing service industry. In some diseases and genes, and at some labs, accuracy exceeds 99% for interpretation of pathogenic variants (see these publications for Hereditary Breast and Ovarian Cancer and Lynch Syndrome). However, in most other disease states within some labs, the chance of getting a positive result that is inaccurate is much greater than getting a positive result that is accurate. Our Patient Education page contains a useful review of difficulties surrounding accurate variant interpretation and what a patient or clinician can do about it. CGI’s Variant FactChecker service is designed to empower the patient and/or clinician who has received a genetic test result and had questions about its interpretation accuracy.

What is CGI’s mission? 2017-09-07T16:46:48+00:00

The Center for Genomic Interpretation (CGI) saves lives. CGI does this by providing an accurate interpretation of patients and consumers’ genetic variants to help guide clinical decision making. CGI works to rapidly reduce the greater than 50% false positive rate averaged across the clinical genetic testing industry. CGI also works to drive down the indeterminable false negative rate in clinical genetics. Thus, CGI drives quality in clinical genetics. Please visit CGI’s mission page.

Is CGI a 501(c)(3) non-profit humanitarian organization? 2017-09-19T20:49:46+00:00

The Center for Genomic Interpretation is a registered nonprofit organization. CGI’s IRS 501(c)(3) determination was effective as of April 2017. Please DONATE now and help make a difference.

Can I donate to CGI, and how much can I donate? 2017-09-19T20:48:50+00:00

Yes, you can donate. Donations help CGI accomplish its life-saving mission. Any amount of money can be donated. All donations are appreciated. As a 501(c)(3), you will receive a receipt for tax deduction purposes. Donate here.

Can I get regular email updates about CGI’s progress? 2017-09-07T16:44:39+00:00

Yes, CGI is eager to keep you in the loop. Please click HERE to enter your contact information to receive periodic updates on CGI’s progress.