Strategic Social Impact Investing 2017-09-19T20:04:06+00:00


Social impact investors desire to make a positive impact on society while driving financial returns. As a 501(c)(3) charitable non-profit the CGI can accept recoverable and convertible grants from investors with the intent to repay after self-sustaining milestones are met. Such recoverable grants are strategically powerful for existing investors in healthcare and genetic testing laboratories, companies, and technologies. By strategically investing in CGI, investors improve their for-profit investment success rate while driving positive societal impact.



Your investment is contributed as a recoverable grant that can be optionally converted at any time to a charitable donation, in part or in full.


Your investment is used by CGI to protect and save lives, develop critical infrastructure, and support and advance the clinical genetic diagnostic market.


Investments in CGI also support our partners by providing them with highest-quality clinical genetic variant interpretations.


CGI’s self-sustaining business model generates revenue to repay the original grant amount plus interest.



How common are hereditary diseases? 2017-09-07T16:48:23+00:00

About 8% of Americans are affected by a rare genetic disease. The percentage is roughly the same in European countries. There are many different kinds of genetic diseases with varying levels of severity. Some ancestral populations have a higher prevalence of certain genetic disease(s) than others. Our Hereditary Diseases page lists many of the genetic diseases.

How accurate is genetic testing? 2017-09-07T16:47:19+00:00

There are two major aspects to a genetic test’s accuracy within a laboratory or company; the ability to detect a genetic variant (with accuracy often exceeding 98% for DNA sequencing), and the ability to accurately interpret the genetic variant once detected. The latter step of interpretation is the focus of the Center for Genomic Interpretation since in most genetic testing cases interpretation it is the step that is subject to the greatest error. A laboratory or company’s ability to accurately interpret genetic variants differs widely across the genetic testing service industry. In some diseases and genes, and at some labs, accuracy exceeds 99% for interpretation of pathogenic variants (see these publications for Hereditary Breast and Ovarian Cancer and Lynch Syndrome). However, in most other disease states within some labs, the chance of getting a positive result that is inaccurate is much greater than getting a positive result that is accurate. Our Patient Education page contains a useful review of difficulties surrounding accurate variant interpretation and what a patient or clinician can do about it. CGI’s Variant FactChecker service is designed to empower the patient and/or clinician who has received a genetic test result and had questions about its interpretation accuracy.

What is CGI’s mission? 2017-09-07T16:46:48+00:00

The Center for Genomic Interpretation (CGI) saves lives. CGI does this by providing an accurate interpretation of patients and consumers’ genetic variants to help guide clinical decision making. CGI works to rapidly reduce the greater than 50% false positive rate averaged across the clinical genetic testing industry. CGI also works to drive down the indeterminable false negative rate in clinical genetics. Thus, CGI drives quality in clinical genetics. Please visit CGI’s mission page.

Is CGI a 501(c)(3) non-profit humanitarian organization? 2017-09-19T20:49:46+00:00

The Center for Genomic Interpretation is a registered nonprofit organization. CGI’s IRS 501(c)(3) determination was effective as of April 2017. Please DONATE now and help make a difference.

Can I donate to CGI, and how much can I donate? 2017-09-19T20:48:50+00:00

Yes, you can donate. Donations help CGI accomplish its life-saving mission. Any amount of money can be donated. All donations are appreciated. As a 501(c)(3), you will receive a receipt for tax deduction purposes. Donate here.

Can I get regular email updates about CGI’s progress? 2017-09-07T16:44:39+00:00

Yes, CGI is eager to keep you in the loop. Please click HERE to enter your contact information to receive periodic updates on CGI’s progress.