Challenges of Genomic Testing for Hereditary Breast and Ovarian Cancers

“At times, the sheer quantity of information provided by NGS leads to more questions than answers, a concept known as the Next-Generation Sequencing Paradox:41 the more genes tested in a panel, the greater the likelihood of VUS detection and the greater the ambiguity of the test results. “

https://pubmed.ncbi.nlm.nih.gov/33488111/