Acceptable Thresholds Committee
The volunteer ELEVATEGENETICS Acceptable Thresholds Committee establishes thresholds for grading the accuracy of clinical genetic and genomic tests. This committee helps fulfill an essential need because many clinical laboratories are running clinical tests that are unverified by any third party, and are too-frequently inaccurate, even when the laboratories are CLIA certified or CAP accredited. Unfortunately, most clinicians, patients, health insurers, and sometimes even the labs themselves are unaware of systematic laboratory failures that too-often lead to inaccurate test results, which can ultimately result in physical as well as financial harm to patients. While different regulatory bodies within the United States focus on different aspects of clinical testing with varying rigor, the nonprofit Center for Genomic Interpretation is the only organization providing test users and payers with a rigorous, unbiased, and systematic way to cross compare the accuracy of competing clinical genetic and genomic tests. The ELEVATEGENETICS Acceptable Thresholds Committee defines the clinically relevant testing “challenges” that participating laboratories will be evaluated against in ELEVATEGENETICS BRILLIANT assessments. The committee also sets the thresholds for accuracy scores by which different types of tests are awarded: Elite, Satisfactory, or Participating grades.
Patient Advocates
Maureen Boesen
BRCA patient; Nipples Optional
Allison Mihalich
NIPT parent
Erika Stallings, J.D.
Co-Founder of Basser Center for BRCA
Courtney Glass, J.D.
BRCA patient
Terri Conneran
Lung cancer survivor; KRAS Kickers
Wenora Johnson
Lynch patient; FORCE
Charles Steward, PhD
Rare Disease Dad
Manju George, PhD
Rectal cancer survivor
Ricki Lewis, PhD
Cancer Survivor & Senior Medical Writer
Clinical & Industry Advocates
Jeff Allen, PhD
President & CEO; Friends of Cancer Research
Mark Fleury, PhD
Policy Development, Emerging Science; American Cancer Society
Nirupama Shridhar, PhD, MPH
State Genetics Coordinator, Washington State Department of Health
Girish Putcha, MD, PhD
Former Director of Lab Services for Palmettos MolDX program
Ranjit Goudar, MD
Hereditary Cancer Clinic Director; Virginia Oncology Associates
Suresh Mukherji, MD, MBA, FACR
National Alliance of Health Care Purchasers Coalition
Lee Ellis, MD
UT MD Anderson Cancer Ctr, ASCO
Robert Cook-Deegan, MD
Founded Duke Center for Genome Ethics, Law and Policy
Gabriela Portugal, MD
Director of Cancer Program and Latina Cancer Survivor Advocate
Alexander Lazar, MD, PhD
Professor of Pathology & Genomic Medicine, MD Anderson
Kevin Knopf, MD, MPH
Chief of Hem/Onc & UCSF Professor on Health Economics
David Seidenwurm, MD
CMO Sutter Medical Foundation- Quality, Value Based Pymts & Safety
Heather E. Williams, PhD, MS, PgD, ErCLG, CG(ASCP)MB
Kim Skellington, CGC
Michael J Sinosich, BSc AIMLS PhD FFScRCPA
(Australia) Scientific Director and Manager Prenatal Testing, DHM Pathology Sonic Healthcare Ltd
Observing Members
Daniel Edelman, PhD FDA
Biologist, Personalized Medicine
Thierry Vilboux, PhD FDA
Senior Staff Fellow, Personalized Medicine
John Pfeifer, MD PhD
Professor, Washington University