
Acceptable Thresholds Committee
The volunteer ELEVATEGENETICS Acceptable Thresholds Committee establishes thresholds for grading the accuracy of clinical genetic and genomic tests. This committee helps fulfill an essential need because many clinical laboratories are running clinical tests that are unverified by any third party, and are too-frequently inaccurate, even when the laboratories are CLIA certified or CAP accredited. Unfortunately, most clinicians, patients, health insurers, and sometimes even the labs themselves are unaware of systematic laboratory failures that too-often lead to inaccurate test results, which can ultimately result in physical as well as financial harm to patients. While different regulatory bodies within the United States focus on different aspects of clinical testing with varying rigor, the nonprofit Center for Genomic Interpretation is the only organization providing test users and payers with a rigorous, unbiased, and systematic way to cross compare the accuracy of competing clinical genetic and genomic tests. The ELEVATEGENETICS Acceptable Thresholds Committee defines the clinically relevant testing “challenges” that participating laboratories will be evaluated against in ELEVATEGENETICS BRILLIANT assessments. The committee also sets the thresholds for accuracy scores by which different types of tests are awarded: Elite, Satisfactory, or Participating grades.
Patient Advocates

Maureen Boesen
BRCA patient; Nipples Optional

Allison Mihalich
NIPT parent

Erika Stallings, J.D.
Co-Founder of Basser Center for BRCA

Courtney Glass, J.D.
BRCA patient

Wenora Johnson
Lynch patient; FORCE

Charles Steward, PhD
Rare Disease Dad

Manju George, PhD
Rectal cancer survivor

Ricki Lewis, PhD
Cancer Survivor & Senior Medical Writer
Clinical & Industry Advocates

Jeff Allen, PhD
President & CEO; Friends of Cancer Research

Mark Fleury, PhD
Policy Development, Emerging Science; American Cancer Society

Nirupama Shridhar, PhD, MPH
State Genetics Coordinator, Washington State Department of Health

Ranjit Goudar, MD
Hereditary Cancer Clinic Director; Virginia Oncology Associates

David Seidenwurm, MD
CMO Sutter Medical Foundation- Quality, Value Based Pymts & Safety

Suresh Mukherji, MD, MBA, FACR
National Alliance of Health Care Purchasers Coalition

Lee Ellis, MD
UT MD Anderson Cancer Ctr, ASCO

Robert Cook-Deegan, MD
Founded Duke Center for Genome Ethics, Law and Policy

Gabriela Portugal, MD
Director of Cancer Program and Latina Cancer Survivor Advocate

Alexander Lazar, MD, PhD
Professor of Pathology & Genomic Medicine, MD Anderson

Kevin Knopf, MD, MPH
Chief of Hem/Onc & UCSF Professor on Health Economics

Michael J Sinosich, BSc AIMLS PhD FFScRCPA
(Australia) Scientific Director and Manager Prenatal Testing, DHM Pathology Sonic Healthcare Ltd

Heather E. Williams, PhD, MS, PgD, ErCLG, CG(ASCP)MB

Kim Skellington, CGC
Observing Members

Daniel Edelman, PhD FDA
Biologist, Personalized Medicine

Thierry Vilboux, PhD FDA
Senior Staff Fellow, Personalized Medicine

John Pfeifer, MD PhD
Professor, Washington University